Restriction of retroviral replication by APOBEC3G/F and TRIM5α
نویسندگان
چکیده
منابع مشابه
Restriction of Retroviral Replication by Tetherin/BST-2
Tetherin/BST-2 is an important host restriction factor that limits the replication of HIV and other enveloped viruses. Tetherin is a type II membrane glycoprotein with a very unusual domain structure that allows it to engage budding virions and retain them on the plasma membrane of infected cells. Following the initial report identifying tetherin as the host cell factor targeted by the HIV-1 Vp...
متن کاملMechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α
Restriction factors and pattern recognition receptors are important components of intrinsic cellular defenses against viral infection. Mammalian TRIM5α proteins are restriction factors and receptors that target the capsid cores of retroviruses and activate ubiquitin-dependent antiviral responses upon capsid recognition. Here, we report crystallographic and functional studies of the TRIM5α B-box...
متن کاملProteasomal Degradation of TRIM5α during Retrovirus Restriction
The host protein TRIM5alpha inhibits retroviral infection at an early post-penetration stage by targeting the incoming viral capsid. While the detailed mechanism of restriction remains unclear, recent studies have implicated the activity of cellular proteasomes in the restriction of retroviral reverse transcription imposed by TRIM5alpha. Here, we show that TRIM5alpha is rapidly degraded upon en...
متن کاملRetroviral Replication
The retroviruses (the taxonomic family Retroviridae) comprise isolates of vertebrates, but elements with hallmarks of retroviruses are also found elsewhere, e.g. in insects. Retroviruses exemplify a variety of specialized interactions with their hosts, including induction of many kinds of diseases under laboratory conditions as well as in domestic and wild animals. In contrast to this variation...
متن کاملTRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition
Restriction factors are important components of intrinsic cellular defense mechanisms against viral pathogens. TRIM5α is a restriction factor that intercepts the incoming capsid cores of retroviruses such as HIV and provides an effective species-specific barrier to retroviral infection. The TRIM5α SPRY domain directly binds the capsid with only very weak, millimolar-level affinity, and producti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Microbiology
سال: 2008
ISSN: 0966-842X
DOI: 10.1016/j.tim.2008.08.013